Polynucleotide Treatmentin Sheffield
Refresh your tired skin, face, neck, under-eyes, décolletage, hands and under-eye dark circles with natural DNA therapy.
Recognised & Accredited
The Essentials
Polynucleotides at a Glance
Procedure Time
30 minutes
Discomfort Level
Mild-Moderate (topical cream)
After completing the course
From 3-4 weeks
Recovery
3-4 days (estimated)
One-off or Course
Course of 3-4
Cost From
£275
The Treatment
What are Polynucleotide Injections?
Polynucleotide injections use natural salmon DNA. They work deep inside your skin, signalling the cells to make fresh collagen and elastin. This repairs your skin at a cellular level and makes it firm again.
Medical-Grade
Doctor-Led Care
How It Works
Cellular Repair & Collagen Boost
Derived from purified salmon DNA, polynucleotides stimulate your skin's natural healing, repairing damaged cells and boosting collagen and elastin for firmer, smoother, more youthful skin.
Moisture Retention & Anti-Inflammatory
Polynucleotides increase the skin's ability to hold moisture while their anti-inflammatory action reduces redness and swelling, making them ideal for dehydrated, acne-prone, and sensitive skin.
The Science
How Do Polynucleotide Injections Work?
We inject polynucleotides into your skin. The salmon sperm (DNA) in the injections helps your skin heal and produce new collagen.
This smooths out lines, clears up crepey skin, and brightens dark marks. You look rested and fresh.
What it Treats
Where Can Polynucleotide Injections Be Used?
Why Patients Love It
Benefits of Polynucleotide Treatment
A regenerative, doctor-led therapy that repairs and rejuvenates the skin from within, improving firmness, hydration, and overall skin quality with minimal downtime.
Boosts collagen for a tighter, younger look.
Works safely with your own body.
Enjoy firm skin for up to a year.
Aftercare
What to Expect After a Polynucleotide Treatment Session
Day 1-3
You may see small bumps (blebs) or mild swelling.
Month 4+
Best results show after your full course. Skin looks smoother.
Month 2+
Your skin starts to look brighter and fresher.
Day 1-3
You may see small bumps (blebs) or mild swelling.
Month 2+
Your skin starts to look brighter and fresher.
Month 4+
Best results show after your full course. Skin looks smoother.
Investment
Polynucleotide Injections Cost
A course of 3 to 4 sessions is recommended for best results. Open a card below to see full pricing and book your treatment.
Polynucleotide Injections (Collagen Booster)
Doctor
£350
Nurse Offer
£275
The Difference
Why Choose Polynucleotide Treatment?
The Skin Firm Specialists
Meet The Team
Doctor-led and expertly delivered. Our team blends medical precision with a genuine passion for natural, confidence-boosting results.
GMC-registered aesthetic doctor with over 17 years of medical experience and a distinguished NHS GP background. Known for precision, deep facial anatomy expertise, and a natural approach to enhancement.
Know MoreDr Naren Senthil Nathan
MBBS · PGCertMedEd · MRCGP · FRCGP
Founder & Clinical Director
NMC-registered Advanced Aesthetic Nurse Injector with years of hands-on experience. Combines clinical precision with an artistic eye to deliver safe, natural-looking results across fillers, anti-wrinkle, and skin boosters.
Know MoreDaisy
BSc (Hons) Adult Nursing · NMC-Registered
Advanced Aesthetic Nurse Injector
Co-founder & Managing Director of The Skin Firm. Combines scientific precision with an artist's eye, helping clients achieve healthy, glowing skin through personalised, evidence-based care.
Know MoreSwathi
Co-founder & Managing Director
Client Stories
What Our Customers Say
Hear from our valued clients about their experiences and the results they've achieved at The Skin Firm.
115+
Google Reviews
Natural & Balanced
I’ve had such an amazing experience here.💕 I’ve now been twice for lip filler and today I had chin filler, and every time the results have been incredible. He is honestly the best so kind, friendly, and professional. He takes the time to explain everything and makes you feel completely at ease. I felt really comfortable knowing my face was in good hands, which is so important with treatments like this. The results are exactly what I wanted, very natural and balanced. I wouldn’t go anywhere else and would highly recommend to anyone thinking about aesthetic treatments. Thank you so much!
Well Looked After
Firstly a consultation and peel with Swathi, she really took the time to listen and give me appropriate advice on how to rejuvenate my skin, which is exactly what I hoped for. Dr Naren removed a milia for me, it was swift, professional and healed very quickly with perfect results. Both of them have an absolutely lovely manner which puts you at ease, instills trust and makes you feel well looked after. I look forward to continuing my treatments with them.
Long-Term Natural Results
If you’re looking to enhance your natural beauty, Dr Naren is simply the man for the job. I wouldn’t go anywhere else. He takes his time, ensures you are comfortable and knowledgeable about what can be achieved. He focuses on long-term natural results rather than quick fixes. My enhanced natural beauty has replaced my previous artificial, unsightly era. I’m sure he applies the same care and magic to all his clients.
In Safe Hands
From the first meeting with Dr Naren I knew I was in safe hands. It was obvious he had the experience and expertise to advise and deliver the best aesthetic advice and treatment for me. He is approachable and very personable. I am delighted with my results and will be returning for sure.
Such A Big Difference
I’ve been getting treatment for my scarring at The Skin Firm, and honestly, they’ve been amazing. The team are so lovely, really know what they’re doing, and always make me feel comfortable. I’ve already noticed such a big difference in my skin, and it’s boosted my confidence so much. Highly recommend them — they’ve been fantastic!
Couldn’t Be Happier
Had an amazing experience at The Skin Firm thanks to Swathi, who took great care in creating a plan to treat my adult acne and aging concerns. I had 3 sessions of chemical peeling + microneedling and I couldn't be happier with the results! My spots and pigmentation are nearly gone. I highly recommend getting an appointment with her!
Exceptional Results
I can’t recommend SkinFirm enough! I’ve visited twice for 1 ml lip filler with Dr. Nayen, and each time he’s delivered exceptional results. He takes the time to explain everything thoroughly and makes you feel completely at ease. SkinFirm will always be my go-to for any aesthetic treatments
Lovely Welcoming Clinic
Lovely welcoming clinic! Dr Naren always takes his time with my appointments and makes sure I feel completely at ease. Very professional and would highly recommend!
Tailored To My Needs
Wonderful relaxing experience in professional yet friendly environment. Natural results and exactly tailored to my needs and request. Highly recommend.
Life-Changing Results
Dr Naren has helped transform my face and confidence more than I could have imagined. His clinic is so friendly and welcoming. He has got a long term client in me. Thank you so much xx
Genuinely Caring
absolutely fantastic experience with Dr Naren and the clinic - friendly, professional and genuinely caring and honest regarding results and potential - highest possible recommendation
Glowing Skin
I had a great experience at the Skin Firm. The Microdermabrasion treatment was done very carefully by Swathi and my skin is glowing today. The price was also very reasonable.
Five-Star Experience
My experience here getting filler was 5 stars! Dr Naren was very friendly and reassuring and made me feel at ease. The treatment process had minimal discomfort and my result was natural and just as I wanted. I would definitely come back again and recommend here to anyone getting filler for the first time.
Listened To
Excellent service and made me feel at easy. I went for an initial consultation but then changed mind, it was easy to switch plan and be listened to. Will be back soon again!
The Best Clinic
Honestly the best clinic I’ve ever to been for my treatments doing , and I’ve been to lots in my 57 years . Dr Naren explained everything thoroughly to me before and during my treatments , and the results I absolutely love. I would 100% recommend him to all my friends , and give 10 stars if I could . ;)
Fantastic & Professional
The entirety of the experience with Dr. Naren and his team was fantastic and very professional. I highly recommend and will be back myself!
Immediately At Ease
Went to the Skin Firm for a treatment with Dr Naren after reading positive reviews. Was greeted warmly by Dr Naren and Swathi and immediately put at ease, very professional and didn't make you feel rushed - taking the time to go through all information and answer any questions. Will definitely be returning !
Natural & Balanced
I’ve had such an amazing experience here.💕 I’ve now been twice for lip filler and today I had chin filler, and every time the results have been incredible. He is honestly the best so kind, friendly, and professional. He takes the time to explain everything and makes you feel completely at ease. I felt really comfortable knowing my face was in good hands, which is so important with treatments like this. The results are exactly what I wanted, very natural and balanced. I wouldn’t go anywhere else and would highly recommend to anyone thinking about aesthetic treatments. Thank you so much!
Well Looked After
Firstly a consultation and peel with Swathi, she really took the time to listen and give me appropriate advice on how to rejuvenate my skin, which is exactly what I hoped for. Dr Naren removed a milia for me, it was swift, professional and healed very quickly with perfect results. Both of them have an absolutely lovely manner which puts you at ease, instills trust and makes you feel well looked after. I look forward to continuing my treatments with them.
Long-Term Natural Results
If you’re looking to enhance your natural beauty, Dr Naren is simply the man for the job. I wouldn’t go anywhere else. He takes his time, ensures you are comfortable and knowledgeable about what can be achieved. He focuses on long-term natural results rather than quick fixes. My enhanced natural beauty has replaced my previous artificial, unsightly era. I’m sure he applies the same care and magic to all his clients.
In Safe Hands
From the first meeting with Dr Naren I knew I was in safe hands. It was obvious he had the experience and expertise to advise and deliver the best aesthetic advice and treatment for me. He is approachable and very personable. I am delighted with my results and will be returning for sure.
Such A Big Difference
I’ve been getting treatment for my scarring at The Skin Firm, and honestly, they’ve been amazing. The team are so lovely, really know what they’re doing, and always make me feel comfortable. I’ve already noticed such a big difference in my skin, and it’s boosted my confidence so much. Highly recommend them — they’ve been fantastic!
Couldn’t Be Happier
Had an amazing experience at The Skin Firm thanks to Swathi, who took great care in creating a plan to treat my adult acne and aging concerns. I had 3 sessions of chemical peeling + microneedling and I couldn't be happier with the results! My spots and pigmentation are nearly gone. I highly recommend getting an appointment with her!
Exceptional Results
I can’t recommend SkinFirm enough! I’ve visited twice for 1 ml lip filler with Dr. Nayen, and each time he’s delivered exceptional results. He takes the time to explain everything thoroughly and makes you feel completely at ease. SkinFirm will always be my go-to for any aesthetic treatments
Lovely Welcoming Clinic
Lovely welcoming clinic! Dr Naren always takes his time with my appointments and makes sure I feel completely at ease. Very professional and would highly recommend!
Tailored To My Needs
Wonderful relaxing experience in professional yet friendly environment. Natural results and exactly tailored to my needs and request. Highly recommend.
Life-Changing Results
Dr Naren has helped transform my face and confidence more than I could have imagined. His clinic is so friendly and welcoming. He has got a long term client in me. Thank you so much xx
Genuinely Caring
absolutely fantastic experience with Dr Naren and the clinic - friendly, professional and genuinely caring and honest regarding results and potential - highest possible recommendation
Glowing Skin
I had a great experience at the Skin Firm. The Microdermabrasion treatment was done very carefully by Swathi and my skin is glowing today. The price was also very reasonable.
Five-Star Experience
My experience here getting filler was 5 stars! Dr Naren was very friendly and reassuring and made me feel at ease. The treatment process had minimal discomfort and my result was natural and just as I wanted. I would definitely come back again and recommend here to anyone getting filler for the first time.
Listened To
Excellent service and made me feel at easy. I went for an initial consultation but then changed mind, it was easy to switch plan and be listened to. Will be back soon again!
The Best Clinic
Honestly the best clinic I’ve ever to been for my treatments doing , and I’ve been to lots in my 57 years . Dr Naren explained everything thoroughly to me before and during my treatments , and the results I absolutely love. I would 100% recommend him to all my friends , and give 10 stars if I could . ;)
Fantastic & Professional
The entirety of the experience with Dr. Naren and his team was fantastic and very professional. I highly recommend and will be back myself!
Immediately At Ease
Went to the Skin Firm for a treatment with Dr Naren after reading positive reviews. Was greeted warmly by Dr Naren and Swathi and immediately put at ease, very professional and didn't make you feel rushed - taking the time to go through all information and answer any questions. Will definitely be returning !
Natural & Balanced
I’ve had such an amazing experience here.💕 I’ve now been twice for lip filler and today I had chin filler, and every time the results have been incredible. He is honestly the best so kind, friendly, and professional. He takes the time to explain everything and makes you feel completely at ease. I felt really comfortable knowing my face was in good hands, which is so important with treatments like this. The results are exactly what I wanted, very natural and balanced. I wouldn’t go anywhere else and would highly recommend to anyone thinking about aesthetic treatments. Thank you so much!
Well Looked After
Firstly a consultation and peel with Swathi, she really took the time to listen and give me appropriate advice on how to rejuvenate my skin, which is exactly what I hoped for. Dr Naren removed a milia for me, it was swift, professional and healed very quickly with perfect results. Both of them have an absolutely lovely manner which puts you at ease, instills trust and makes you feel well looked after. I look forward to continuing my treatments with them.
Long-Term Natural Results
If you’re looking to enhance your natural beauty, Dr Naren is simply the man for the job. I wouldn’t go anywhere else. He takes his time, ensures you are comfortable and knowledgeable about what can be achieved. He focuses on long-term natural results rather than quick fixes. My enhanced natural beauty has replaced my previous artificial, unsightly era. I’m sure he applies the same care and magic to all his clients.
In Safe Hands
From the first meeting with Dr Naren I knew I was in safe hands. It was obvious he had the experience and expertise to advise and deliver the best aesthetic advice and treatment for me. He is approachable and very personable. I am delighted with my results and will be returning for sure.
Such A Big Difference
I’ve been getting treatment for my scarring at The Skin Firm, and honestly, they’ve been amazing. The team are so lovely, really know what they’re doing, and always make me feel comfortable. I’ve already noticed such a big difference in my skin, and it’s boosted my confidence so much. Highly recommend them — they’ve been fantastic!
Couldn’t Be Happier
Had an amazing experience at The Skin Firm thanks to Swathi, who took great care in creating a plan to treat my adult acne and aging concerns. I had 3 sessions of chemical peeling + microneedling and I couldn't be happier with the results! My spots and pigmentation are nearly gone. I highly recommend getting an appointment with her!
Exceptional Results
I can’t recommend SkinFirm enough! I’ve visited twice for 1 ml lip filler with Dr. Nayen, and each time he’s delivered exceptional results. He takes the time to explain everything thoroughly and makes you feel completely at ease. SkinFirm will always be my go-to for any aesthetic treatments
Lovely Welcoming Clinic
Lovely welcoming clinic! Dr Naren always takes his time with my appointments and makes sure I feel completely at ease. Very professional and would highly recommend!
Tailored To My Needs
Wonderful relaxing experience in professional yet friendly environment. Natural results and exactly tailored to my needs and request. Highly recommend.
Life-Changing Results
Dr Naren has helped transform my face and confidence more than I could have imagined. His clinic is so friendly and welcoming. He has got a long term client in me. Thank you so much xx
Genuinely Caring
absolutely fantastic experience with Dr Naren and the clinic - friendly, professional and genuinely caring and honest regarding results and potential - highest possible recommendation
Glowing Skin
I had a great experience at the Skin Firm. The Microdermabrasion treatment was done very carefully by Swathi and my skin is glowing today. The price was also very reasonable.
Five-Star Experience
My experience here getting filler was 5 stars! Dr Naren was very friendly and reassuring and made me feel at ease. The treatment process had minimal discomfort and my result was natural and just as I wanted. I would definitely come back again and recommend here to anyone getting filler for the first time.
Listened To
Excellent service and made me feel at easy. I went for an initial consultation but then changed mind, it was easy to switch plan and be listened to. Will be back soon again!
The Best Clinic
Honestly the best clinic I’ve ever to been for my treatments doing , and I’ve been to lots in my 57 years . Dr Naren explained everything thoroughly to me before and during my treatments , and the results I absolutely love. I would 100% recommend him to all my friends , and give 10 stars if I could . ;)
Fantastic & Professional
The entirety of the experience with Dr. Naren and his team was fantastic and very professional. I highly recommend and will be back myself!
Immediately At Ease
Went to the Skin Firm for a treatment with Dr Naren after reading positive reviews. Was greeted warmly by Dr Naren and Swathi and immediately put at ease, very professional and didn't make you feel rushed - taking the time to go through all information and answer any questions. Will definitely be returning !
Questions
Frequently Asked Questions
Everything you need to know about polynucleotide treatment at The Skin Firm. Still have questions? Our team is happy to talk you through your options.
Contact Us
Get In Touch
Opening Hours
Our Location
479 Ecclesall Road,
Sheffield S11 8PP, UK
Your Radiant & Healthier Skin Awaits!
Request a call back and our team will get in touch to discuss the right treatment for you.