Polynucleotides Benefits: A Clinical Guide to Skin Rejuvenation

Polynucleotides are short chains of nucleotides, the natural building blocks that form DNA. The polynucleotides used in aesthetic medicine are derived from purified fragments of salmon DNA, which are highly similar to human DNA.

These components work when introduced into the dermal layer to stimulate natural healing. These do not function as fillers but rather stimulate the skin cells to increase collagen and elastin production.

The therapy provides an array of structural and aesthetic enhancements. Listed below are the most clinically significant polynucleotide skin benefits.

1. Increases Collagen and Elastin Production

Polynucleotides stimulate fibroblast activity, improving dermal structure. It overcomes the visibility of wrinkles, fine lines, and sagging skin.

2. Aids Skin Repair

This treatment helps speed up skin cell recovery. It can help to treat skin damage, such as acne scars and post-inflammatory hyperpigmentation.

3. Improves Skin Elasticity

Studies show polynucleotides can increase skin elasticity by an average of 22 per cent within weeks of treatment. The result is firmer, more resilient skin.

4. Reduces Under-Eye Dark Circles

Clinical results indicate under-eye brightness improves by over 32 per cent within four weeks of treatment. The therapy reduces pigmentation and discolouration in the periorbital area.

5. Increases Hydration

These polynucleotides trigger increased hyaluronic acid production, which hydrates the skin from within.

6. Protection against Free Radicals

These molecules contain antioxidants that protect the skin from damage by free radicals, which cause premature skin ageing.

7. Increases Cell Turnover

Faster cell turnover leads to fresher, smoother skin and a more even complexion. These combined advantages of polynucleotides make the therapy a strong option for long-term skin health rather than short-term correction.

Polynucleotide therapy treats a wide range of skin concerns, particularly those linked to ageing, texture, and pigmentation. Suitable concerns include:

• Fine lines and wrinkles
• Skin laxity
• Crepey skin texture
• Under-eye dark circles
• Under-eye bags
• Fine lines around the eyes
• Acne scarring
• Mild pigmentation

The treatment also helps individuals with dry, dehydrated, or sensitive skin, for whom stronger options may not be suitable.

Doctors can safely use this treatment on different areas of the face and body:

If you wonder how to refresh tired-looking eyes, a structured course of regenerative injections often delivers more natural results than traditional fillers. Learn more about our polynucleotide treatment.

Polynucleotides activate the skin's natural healing process. Once injected into the dermal layers, they:

• Stimulate fibroblast cells to produce collagen and elastin.
• Regenerate damaged skin cells rather than replace them.
• Increase hyaluronic acid production for intensive moisture.
• Decreases inflammation, helping to calm acne-prone and sensitive skin.
• Promote cell turnover for smoother skin.

The treatment works gradually. First visible improvements typically appear around two to three weeks after the initial session, with full results visible at approximately twelve weeks.

Polynucleotide therapy suits most skin types. However, certain groups should avoid this treatment.

A medical consultation determines individual suitability based on skin assessment and history.

The procedure is straightforward and methodical.

Compared to other injections, it has a somewhat “stingy” effect, though the numbing cream makes it quite easy to tolerate.

Polynucleotide therapy involves minimal downtime. Recovery depends on the technique used.

Patients normally resume their usual activities shortly after treatment. Patients should refrain from exercising, exposure to heat, and the use of skincare products for 24 to 48 hours.

You can achieve the best results by following a proper treatment plan rather than relying on a single session.

Skipping a session or prolonging the period decreases regeneration results.

The results from a full treatment course usually last for nine to twelve months. Several factors determine the duration:

• Metabolism of the individual
• Lifestyle and stress levels
• Nutrition and hydration
• Exposure to sunlight
• Skin care regimen
• Tobacco and alcohol consumption

An annual maintenance treatment can ensure that the results last longer.

While polynucleotides have a strong safety profile, all injectable treatments carry potential risks. Patients should be aware of:

• Slight inflammation, redness, or bruising at the site of injection
• Temporary pain for 24 to 48 hours
• Small blisters (with needle technique), persisting up to three days
• Allergic reaction, but very uncommon in patients with fish allergy
• Infections, if appropriate after-injection procedures are not followed

The selection of a professionally licensed practitioner substantially lowers these potential hazards. Polynucleotides cannot be self-applied.

Benefits of using polynucleotides include stimulation of collagen and elastin, improved skin elasticity, enhanced tissue healing, reduced under-eye darkness, and skin health preservation. This therapy affects the body at the cellular level rather than externally, which makes it a clinically recognised procedure that provides natural results.

The results depend on choosing the right patient, using good-quality polynucleotides, and the skill of the doctor giving the treatment. Injections of polynucleotides into sensitive areas, such as the under-eye area, require medical expertise.

If you would like to explore whether this treatment suits your skin, consult the medically qualified team at The Skin Firm for a personalised assessment with Dr Naren.